Michael Anthony here, reporting on another staple of my supplements for heart health and so much more. This one is very inexpensive. The following video gives you a ton of info on the topic, that obviously Big Pharma doctors do not want you to know. Facts are the enemy of Big Pharma, and the Democrats in almost all things. I’ve done the research for you, tested three products myself and previously reported on a product that I use almost daily that comes from Sweden, called Naked
I wrote an article on this and Glycine that has helped our readers all over the world. – –
The Powerful Duo: Bone Broth and Glycine for Gut Health, Sleep, and Overall Wellness
Here’s an even deeper dive into Glycine that info and health nuts will appreciate. In our modern Western diets dominated by muscle meats, processed foods, and minimal collagen-rich foods like bone broth or skin, most people are unknowingly running a glycine deficit. A compelling interview-style video from Paleovalley (featuring biochemist Dr. Joel Brind) highlights this issue: typical intake hovers around 2–3g per day, far below what our bodies may need for optimal anti-inflammatory and metabolic function—potentially around 10g total daily.
Dr. Brind, a Yale-trained researcher with decades in immunology and nutrition, and author of The Glycine Miracle, argues that this shortfall turns routine micro-injuries (like those in artery walls from blood flow turbulence) into chronic inflammation drivers. Glycine acts as a “brake” on overactive immune cells via glycine-gated chloride channels, raising the activation threshold for macrophages and other responders. Without enough, minor stressors spark excessive responses, contributing to plaque buildup, clotting risks, and broader chronic diseases. Continued below the video
The Heart Disease Connection
Heart attacks and cardiovascular disease (CVD) often stem from chronic low-grade inflammation damaging endothelial cells. In glycine deficiency:
- Everyday arterial micro-injuries provoke prolonged inflammatory cascades, promoting atherosclerosis and thrombosis.
- Glycine supports endothelial health, reduces platelet aggregation (a natural blood-thinning effect), and protects against ischemia/reperfusion injury.
- Observational data consistently links higher plasma glycine to lower risk of myocardial infarction (MI) and coronary heart disease (CHD).
Mendelian randomization (MR) studies provide stronger causal hints: genetically higher glycine levels associate with reduced CHD risk (e.g., OR ~0.84–0.95 in European and East Asian analyses), partly mediated by lower blood pressure. Animal models reinforce this—glycine supplementation reduces infarct size, fibrosis, and improves cardiac function post-injury via pathways like GCN2/AKT, while boosting glutathione for antioxidant defense.
One review notes glycine’s dual benefits on lipid and glucose metabolism, while other work shows it mitigates oxidative stress in atherosclerosis models (e.g., via DT-109, a glycine-based compound). Dr. Brind’s strong hypothesis—”to have a heart attack, you probably need to be glycine deficient” (barring extremes)—aligns with these mechanisms, though it’s not absolute immunity and requires more large-scale RCTs.
Note on balance: Not all studies show strong anti-atherosclerotic effects in every model, and MR evidence for CAD is sometimes modest. Glycine shines more clearly for inflammation, metabolic support, and secondary cardiac protection than as a standalone cure-all.
Broader Benefits Backed by Evidence
Glycine is a conditionally essential amino acid, critical for collagen (it’s ~1/3 of collagen’s structure), glutathione synthesis, creatine, and more. Supplementation helps close the gap as we age or face metabolic stress.
- Sleep and Recovery: 3g before bed improves sleep quality in studies—deeper rest without sedation. Higher doses aid joint comfort and exercise recovery.
- Metabolic Health: Improves insulin sensitivity, lowers triglycerides/liver enzymes, and supports weight management in obesity/metabolic syndrome trials. It counters effects of high-methionine diets.
- Anti-Inflammatory and Antioxidant: Suppresses NF-κB, reduces pro-inflammatory cytokines (TNF-α, IL-6), and boosts glutathione. Beneficial in models of colitis, arthritis, and oxidative stress.
- Longevity and Aging: Supports mitochondrial function (often paired with NAC as GlyNAC), reduces hallmarks of aging, and shows geroprotective potential in reviews.
- Other Areas: Potential for schizophrenia symptoms, gut health, and neuroprotection; safe even at higher doses.
Practical Tips:
- Sources: Bone broth, collagen/gelatin, or pure powder (e.g., split doses).
- Stack ideas: With NAC for glutathione; vitamin C for collagen.
- Consult a doctor, especially with CVD, kidney issues, or medications.
Glycine fits perfectly into biohacking routines focused on reducing chronic inflammation alongside diet, exercise, and sleep. It’s low-risk, evidence-backed support—not a miracle, but a smart addition for heart health and vitality.
The product I buy now and have settled on with the Bone Broth as well (details here) is the following. “As an Amazon Associate I earn from qualifying purchases.”
References
- The effect of glycine administration on the characteristics of physiological systems in human adults: A systematic review
- Glycine: The Smallest Anti-Inflammatory Micronutrient
- Assessing the causal association of glycine with risk of cardio-metabolic diseases (Nature Communications)
- Glycine promotes cardiomyocyte proliferation and heart regeneration
- Effects of glycine on metabolic syndrome components: a review
- Induction of glutathione biosynthesis by glycine-based treatment mitigates atherosclerosis
- Research Breakdown on Glycine – Examine
- Glycine Dosage Guide (2026)
See more articles and videos
- Michael Anthony Health at Choice
- Longevity Articles – Choice – Whatfinger News
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